Familial Hypercholesterolemia with Cholesteryl Ester Transfer Protein Deficiency.
نویسندگان
چکیده
منابع مشابه
Is cholesteryl ester transfer protein (CETP) deficiency atherogenic in familial hypercholesterolemia.
Atherosclerosis is considered to be caused by many risk factors. Epidemiological studies have shownthat the co-existence of multiple risk factors contributes to the progress in the disease more heavily than a single risk factor. A high level of LDLis a very strong risk factor for coronary heart disease (CHD), showing the high incidence of angina or myocardial infarction in familial hypercholest...
متن کاملRelationship between cholesteryl ester transfer protein and LDL heterogeneity in familial hypercholesterolemia.
Small, dense LDL particles have been associated with an increased risk of coronary artery disease, and cholesteryl ester transfer protein (CETP) has been suggested to play a role in LDL particle remodeling. We examined the relationship between LDL heterogeneity and plasma CETP mass in familial hypercholesterolemia (FH). LDL particles were characterized by polyacrylamide gradient gel electrophor...
متن کاملCholesteryl Ester Transfer Protein (CETP) Deficiency and CETP Inhibitors
Epidemiologic studies have shown that low-density lipoprotein cholesterol (LDL-C) is a strong risk factor, whilst high-density lipoprotein cholesterol (HDL-C) reduces the risk of coronary heart disease (CHD). Therefore, strategies to manage dyslipidemia in an effort to prevent or treat CHD have primarily attempted at decreasing LDL-C and raising HDL-C levels. Cholesteryl ester transfer protein ...
متن کاملApolipoprotein composition of HDL in cholesteryl ester transfer protein deficiency.
Our purpose was to compare HDL subpopulations, as determined by nondenaturing two-dimensional gel electrophoresis followed by immunoblotting for apolipoprotein A-I (apoA-I), apoA-II, apoA-IV, apoCs, and apoE in heterozygous, compound heterozygous, and homozygous subjects for cholesteryl ester transfer protein (CETP) deficiency and controls. Heterozygotes, compound heterozygotes, and homozygotes...
متن کاملPlasma cholesteryl ester transfer protein.
The plasma lipoproteins are continuously remodeled during their transit through the plasma compartment, owing to the action of lipid metabolizing enzymes and lipid transfer processes. These activities have a major effect on the composition, size, and concentration of the lipoproteins. Lipid transfer processes involving neutral lipids and phospholipids are mediated by specialized plasma proteins...
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ژورنال
عنوان ژورنال: Internal Medicine
سال: 1998
ISSN: 0918-2918,1349-7235
DOI: 10.2169/internalmedicine.37.523